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Thus, oxycodone needs to be administered with warning in clients with pancreatitis and ailments in the biliary tract.Ritonavir or lopinavir/ritonavir greatly improve plasma concentrations of oxycodone in healthful human volunteers as a result of inhibition of CYP3A4 and CYP2D6.[58] Rifampicin drastically cuts down plasma concentrations of oxycodone